Description

Methylbromo(4-Fluorophenyl)Acetate is a specialized fluorinated organic bromide ester, a key building block in advanced synthetic chemistry. This compound matters for its role as a versatile intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing fluorinated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) containing a fluorophenyl moiety, particularly for candidates in CNS and metabolic disease research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the 4-fluorophenyl group enhances biological activity and stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic components in electronic and display materials, improving charge transport and thermal stability.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Peptidomimetic & Prodrug Development: Utilized to introduce fluorinated aromatic esters into peptide backbones or as a prodrug linker to modulate lipophilicity and metabolic profile.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and fluorophore tags for studying enzyme function and cellular localization.

Basic Information

Product Name	Methylbromo(4-Fluorophenyl)Acetate
CAS No.	72191-41-4
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	Methyl 2-bromo-2-(4-fluorophenyl)acetate; 2-Bromo-2-(4-fluorophenyl)acetic acid methyl ester; Methyl α-bromo-4-fluorophenylacetate; (4-Fluorophenyl)(bromo)acetic acid methyl ester; Bromo(4-fluorophenyl)acetic acid methyl ester; Methyl bromo(p-fluorophenyl)acetate; α-Bromo-4-fluorophenylacetic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methylbromo(4-Fluorophenyl)Acetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.