Description

5'-Chloroacetamido-5'-Deoxythymidine is a specialized nucleoside derivative, a key synthetic intermediate in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of modified oligonucleotides and nucleotide-based prodrugs, enabling targeted therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer therapies, and novel molecular probes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside analog prodrugs and antiviral agents.
• Antiviral Drug Research: Used in the development of targeted therapies against viral infections by serving as a precursor for active metabolites.
• Anticancer Agent Development: Employed in the research of chemotherapeutic compounds that target DNA synthesis and repair mechanisms in cancer cells.
• Oligonucleotide Synthesis: Acts as a modified monomer for creating labeled or functionally enhanced DNA/RNA strands for diagnostic and therapeutic applications.
• Biochemical Research: Serves as a tool compound in enzymatic studies and for investigating nucleotide metabolism pathways.
• Molecular Probe Development: Utilized to create affinity probes for studying protein-nucleic acid interactions.

Basic Information

Product Name	5'-Chloroacetamido-5'-Deoxythymidine
CAS No.	72164-50-2
Molecular Formula	C12H16ClN3O5
Molecular Weight	317.73 g/mol
Synonyms	5'-Chloroacetamidothymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2,4-dioxopyrimidin-1-ium-3-olate 5'-(2-chloroacetamide); 5'-Deoxy-5'-(2-chloroacetamido)thymidine; 5'-O-(Chloroacetyl)amino-5'-deoxythymidine; 5'-Chloroacetamido-2'-deoxythymidine; N-[5-Deoxy-5-(thymidin-5-yl)]-2-chloroacetamide
EINECS	Contact for details

Quality Control

Our 5'-Chloroacetamido-5'-Deoxythymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.