Description

Phenacetin-Ethoxy-1-13C is a stable isotope-labeled analog of the analgesic compound phenacetin, where the carbon-13 isotope is specifically incorporated into the ethoxy group. This precise labeling is critical for applications requiring high sensitivity and specificity in analytical detection and metabolic pathway tracing. It is an essential research-grade material for pharmaceutical development, forensic analysis, and advanced biochemical studies where accurate quantification and tracking are paramount.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Serves as a critical reference standard in LC-MS and GC-MS analyses for the accurate quantification of phenacetin and related compounds in complex biological matrices.
• Metabolic Pathway Tracing: Used in pharmacokinetic and drug metabolism studies to elucidate the biotransformation pathways and excretion profiles of phenacetin.
• Pharmaceutical Reference Standard: Employed in the development, validation, and quality control of analytical methods for pharmaceutical formulations and impurity profiling.
• Forensic and Clinical Toxicology: Acts as a definitive standard for the identification and quantification of phenacetin in forensic investigations and clinical toxicology screenings.
• Biochemical Research: Utilized as a tracer in mechanistic studies of enzyme activity and protein binding where the ethoxy moiety is involved.
• Stable Isotope Dilution Assays (SIDA): Provides the labeled component essential for highly accurate and precise quantification assays based on isotope dilution principles.

Basic Information

Product Name	Phenacetin-Ethoxy-1-13C
CAS No.	72156-72-0
Molecular Formula	C10H1313CNO2
Molecular Weight	180.20 g/mol (for 13C1 labeled)
Synonyms	1-(4-Ethoxyphenyl)acetamide-ethoxy-1-13C; N-(4-Ethoxyphenyl)acetamide-ethoxy-1-13C; Acetophenetidin-ethoxy-1-13C; 4'-Ethoxyacetanilide-ethoxy-1-13C; p-Ethoxyacetanilide-ethoxy-1-13C; Phenacetin-1-13C (ethoxy labeled); [1-13C]Ethoxy Phenacetin; Stable Isotope Labeled Phenacetin
EINECS	Contact for details

Quality Control

Our Phenacetin-Ethoxy-1-13C is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to cGMP principles for research chemicals, ensuring traceability and consistency for critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from light. For long-term storage, consider storing under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.