Description

2-(1-Hydroxyethyl)-7-(2-Hydroxy-3-Isopropylaminopropoxy)Benzofuran Glucuronide is a specialized glucuronide conjugate of a benzofuran derivative, representing a key metabolite or synthetic intermediate in advanced pharmaceutical research. This compound is critical for studies involving drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract manufacturing organizations (CMOs) engaged in the synthesis and characterization of complex active pharmaceutical ingredients (APIs) and their metabolites.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for analytical method development and validation in bioanalytical laboratories.
• Metabolite Research: Used as a definitive metabolite standard in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to understand the metabolic pathways of parent drug compounds.
• Preclinical & Clinical Development: Employed in the synthesis and scaling of drug metabolites required for toxicological and pharmacological profiling during drug development stages.
• Impurity Characterization: Acts as a critical tool for identifying and quantifying process-related impurities or degradation products in API batches, ensuring product quality and regulatory compliance.
• Bioconjugation Studies: Provides a model compound for investigating glucuronidation processes and enzyme kinetics related to Phase II drug metabolism.

Basic Information

Product Name	2-(1-Hydroxyethyl)-7-(2-Hydroxy-3-Isopropylaminopropoxy)Benzofuran Glucuronide
CAS No.	72142-73-5
Molecular Formula	C22H31NO10
Molecular Weight	469.49 g/mol
Synonyms	7-[2-Hydroxy-3-(isopropylamino)propoxy]-2-(1-hydroxyethyl)benzofuran glucuronide; 2-(1-Hydroxyethyl)-7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-β-D-glucopyranosiduronic acid; Benzofuran glucuronide metabolite; 72142-73-5; (2R,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[2-(1-hydroxyethyl)-7-[2-hydroxy-3-(propan-2-ylamino)propoxy]benzofuran-3-yl]oxyoxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(1-Hydroxyethyl)-7-(2-Hydroxy-3-Isopropylaminopropoxy)Benzofuran Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the identity, purity (typically >95% by HPLC), and impurity profile to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. For long-term storage, consider storing desiccated at -20°C. The compound is light-sensitive; all handling should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.