Description

Mastoparan CAS NO 72093-21-1 is a cationic, amphipathic tetradecapeptide toxin originally isolated from wasp venom. This bioactive peptide is a potent, non-selective activator of heterotrimeric G proteins, making it a critical research tool for studying G protein-coupled receptor (GPCR) signaling pathways and mast cell degranulation. It is essential for researchers and developers in the fields of cell biology, pharmacology, and neuroscience, serving as a key reagent for investigating cellular secretion, ion channel activity, and intracellular signal transduction mechanisms.

Application

• GPCR Signaling Research: Used as a direct activator of Gi/Go and Gq family G proteins to bypass receptor activation and study downstream effector mechanisms.
• Mast Cell & Secretion Studies: Employed to induce histamine and cytokine release from mast cells and other secretory cells for immunological and inflammatory research.
• Antimicrobial & Anticancer Agent Development: Investigated for its membrane-disrupting properties and potential to induce apoptosis in cancer cells.
• Neuroscience & Ion Channel Modulation: Applied in studies of neurotransmitter release and the modulation of calcium and potassium channels in neuronal tissues.
• Cell Permeabilization Tool: Utilized to create transient pores in cell membranes for introducing impermeable molecules into the cytoplasm.
• Biochemical Assay Standard: Serves as a reference standard in assays measuring phospholipase C activity, adenylate cyclase inhibition, or intracellular calcium mobilization.

Basic Information

Product Name	Mastoparan
CAS No.	72093-21-1
Molecular Formula	C78H131N25O20
Molecular Weight	1690.0 g/mol
Synonyms	Mastoparan I; Mastoparan from Vespula lewisii; INLKALAALAKKIL-NH2 (amide form); Tetradecapeptide mastoparan; G-protein activator peptide; Vespula lewisii mast cell degranulating peptide; Mast cell degranulating peptide-I; MCDP-I
EINECS	Contact for details

Quality Control

Our Mastoparan is produced and analyzed under stringent conditions to ensure the highest standards of identity, purity, and biological activity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity by HPLC, amino acid analysis, and mass spectrometry. We adhere to GMP principles for research-grade peptides, ensuring traceability, consistency, and reliability for your critical experiments. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Amino Acid Composition	Conforms to theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.