Description

Anthopleurin B is a potent polypeptide neurotoxin isolated from sea anemones, specifically recognized by the CAS registry number 72067-68-6. This compound is a critical research tool for studying voltage-gated sodium channels, offering high specificity and biological activity. It is primarily utilized by pharmaceutical researchers, toxicologists, and academic institutions engaged in neuroscience, cardiac physiology, and novel drug discovery programs.

Application

• Neuroscience Research: As a specific modulator of voltage-gated sodium channels (Nav1.1, Nav1.2, Nav1.4, Nav1.5, Nav1.6), it is used to investigate channel kinetics, neuronal excitability, and signal transduction pathways.
• Cardiac Electrophysiology Studies: Employed in research on cardiac sodium channels (Nav1.5) to model arrhythmias and study the effects of channelopathies.
• Pharmacological Probe Development: Serves as a molecular template and reference standard for developing new analgesic or anti-arrhythmic drug candidates targeting sodium channels.
• Toxicology and Venom Research: Used as a reference toxin in comparative studies of marine venoms and in the development of detection assays or antivenoms.
• Biochemical Assay Standard: Acts as a high-purity standard in activity-based assays, receptor binding studies, and for calibrating analytical methods like HPLC and mass spectrometry.
• Academic & Institutional Research: Fundamental research tool in university and government labs for teaching and exploring ion channel structure-function relationships.

Basic Information

Item	Detail
Product Name	Anthopleurin B
CAS No.	72067-68-6
Molecular Formula	C~170~H~268~N~52~O~52~S~4
Molecular Weight	~4.9 kDa
Synonyms	Anthopleurin-B; AP-B; Sea Anemone Sodium Channel Toxin; Sodium Channel Neurotoxin; ATX II (related toxin); Anthopleurin B (CAS 72067-68-6); Anemonia sulcata Toxin II (Homolog); Voltage-Gated Sodium Channel Toxin; Polypeptide Neurotoxin APB
EINECS	Contact for details

Quality Control

Every batch of Anthopleurin B is produced and analyzed under stringent quality management protocols to ensure identity, purity, and biological activity. Our quality commitment includes comprehensive testing via HPLC for purity, mass spectrometry for identity confirmation, and functional bioassays to verify specific sodium channel activity. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Biological Activity	Verified by sodium channel assay
Water Content (KF)	≤ 5.0 %
Endotoxin Level	< 1.0 EU/µg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.