Description

1-[3-(Trifluoromethyl)Phenyl]Piperidin-4-Ol is a high-purity, functionalized piperidine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring a trifluoromethylphenyl group, is engineered to impart desirable physicochemical properties to target molecules, such as enhanced metabolic stability and lipophilicity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored electronic or surface properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Phenyl]Piperidin-4-Ol
CAS No.	71989-92-9
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	4-Piperidinol, 1-[3-(trifluoromethyl)phenyl]-; 1-(3-Trifluoromethylphenyl)piperidin-4-ol; 1-(3-(Trifluoromethyl)phenyl)piperidin-4-ol; 4-Hydroxy-1-(3-trifluoromethylphenyl)piperidine; 1-(α,α,α-Trifluoro-m-tolyl)-4-piperidinol; 71989-92-9; m-Trifluoromethylphenylpiperidinol
EINECS	Contact for details

Quality Control

Our 1-[3-(Trifluoromethyl)Phenyl]Piperidin-4-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide full traceability and detailed Certificates of Analysis (COA) to ensure compliance with your project specifications and support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.