Description

Fmoc-L-Methionine CAS NO 71989-28-1 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). It serves as a critical building block for the controlled introduction of the methionine residue, enabling the production of complex peptides and biopharmaceuticals. This compound is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in drug discovery, proteomics, and the synthesis of therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of peptide chains on resin supports.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including hormone analogs and antimicrobial peptides.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive compounds and drug candidates.
• Bioconjugation: Facilitates the site-specific modification of proteins and other biomolecules for diagnostic and therapeutic applications.
• Academic & Industrial Research: A standard reagent in laboratories studying protein structure, function, and peptide chemistry.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of peptides for clinical and commercial use.

Basic Information

Product Name	Fmoc-L-Methionine
CAS No.	71989-28-1
Molecular Formula	C₂₀H₂₁NO₄S
Molecular Weight	371.45 g/mol
Synonyms	Fmoc-Met-OH; N-(9-Fluorenylmethoxycarbonyl)-L-methionine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-(methylsulfanyl)butanoic acid; Fmoc-L-Met; N-Fmoc-L-methionine; Fmoc-Methionine; L-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-α-Fmoc-L-methionine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Methionine is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, typically meeting or exceeding 98.5% (HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as assay, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable, ensuring the material is suitable for demanding research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]²⁰D	-20.0° to -24.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.