Description

Substance P CAS NO 71977-09-8 is a potent neuropeptide belonging to the tachykinin family, primarily known for its role as a neurotransmitter and neuromodulator. This undecapeptide is critical for research and development in neuroscience, immunology, and pain management due to its involvement in transmitting pain signals, regulating inflammation, and modulating immune responses. It is an essential reagent for pharmaceutical R&D, academic research, and diagnostic assay development, serving scientists and manufacturers focused on neurological disorders, inflammatory diseases, and novel therapeutic discovery.

Application

• Neuroscience Research: Fundamental studies on neurotransmission, nociception (pain perception), and the central/peripheral nervous system function.
• Drug Discovery & Development: A key target and tool compound for screening and developing novel analgesics, anti-inflammatory agents, and neurokinin-1 (NK1) receptor antagonists.
• Immunology & Inflammation Studies: Investigation of its pro-inflammatory effects and role in conditions like arthritis, asthma, and inflammatory bowel disease.
• Cell Biology & Signaling Pathways: Used to study G-protein coupled receptor (GPCR) activation, intracellular calcium mobilization, and mitogen-activated protein kinase (MAPK) pathways.
• Diagnostic & Assay Development: Critical component in the development of immunoassays (ELISA, RIA) and receptor binding assays for clinical research and biomarker analysis.
• Academic & Pharmaceutical R&D: Serves as a standard reference material in university laboratories, contract research organizations (CROs), and biopharmaceutical companies.

Basic Information

Product Name	Substance P
CAS No.	71977-09-8
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.63 g/mol
Synonyms	Substance P (human, bovine, canine, guinea pig, mouse, pig, rabbit, rat); Neurokinin P; SP; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; Tachykinin, precursor 1; TAC1; Neurokinin-1 Receptor Ligand; NK-1 Agonist
EINECS	Contact for details

Quality Control

Our Substance P is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to guarantee reproducibility and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assayed by functional cell-based assay (Available on request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.