Description

Desmethylmianserin is a key pharmaceutical intermediate and metabolite of the antidepressant Mianserin. This compound is of significant interest for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug metabolism studies, impurity profiling, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis and research of tricyclic antidepressant compounds and related analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Studies: Essential for in-vitro and in-vivo drug metabolism and pharmacokinetics (DMPK) research to understand the biotransformation pathways of Mianserin.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of active pharmaceutical ingredients (APIs) during manufacturing.
• Biochemical Research: A tool for investigating the mechanism of action, receptor binding affinity, and structure-activity relationships (SAR) of serotonergic and noradrenergic compounds.

Basic Information

Product Name	Desmethylmianserin
CAS No.	71936-92-0
Molecular Formula	C₁₇H₁₈N₂
Molecular Weight	250.34 g/mol
Synonyms	1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine; Demethylmianserin; Nor-Mianserin; 6H-Pyrazino[1,2-a][1]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-; Mianserin Impurity C; Mianserin Metabolite
EINECS	Contact for details

Quality Control

Our Desmethylmianserin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting standards for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.