Description

n-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a synthetic hexapeptide derivative, commonly utilized as a potent and specific formyl peptide receptor (FPR) agonist in advanced biochemical research. Its primary value lies in its role as a critical tool for studying neutrophil chemotaxis, inflammation pathways, and immune system signaling mechanisms. This compound is essential for researchers and developers in the fields of immunology, pharmacology, and drug discovery, particularly for those investigating anti-inflammatory therapeutics and receptor-ligand interactions.

Application

• Biochemical Research: A standard agonist for formyl peptide receptor (FPR) studies, used to elucidate mechanisms of neutrophil activation and chemotaxis.
• Immunology Studies: Critical for in vitro and in vivo models of inflammation to understand and modulate immune responses.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening assays for identifying novel FPR antagonists or modulators.
• Signal Transduction Research: Used to investigate intracellular calcium mobilization and G-protein coupled receptor (GPCR) signaling pathways.
• Academic & Pharmaceutical R&D: A key reagent for universities, research institutes, and pharmaceutical companies developing new anti-inflammatory agents.

Basic Information

Product Name	n-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys
CAS No.	71901-21-8
Molecular Formula	C46H68N8O10
Molecular Weight	893.1 g/mol
Synonyms	Formyl-Norleucyl-Leucyl-Phenylalanyl-Norleucyl-Tyrosyl-Lysine; fNle-Leu-Phe-Nle-Tyr-Lys; fNLPNTL; Formyl Peptide Receptor Agonist; Chemotactic Peptide fNleLFNleYK; N-Formyl-Met-Leu-Phe-Nle-Tyr-Lys Analog; For-Nle-Leu-Phe-Nle-Tyr-Lys-OH; CHO-Nle-Leu-Phe-Nle-Tyr-Lys
EINECS	Contact for details

Quality Control

Our n-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to industry best practices, and specifications can be aligned with customer requirements for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.