Description

Dithio-Bis-Maleimidoethane CAS NO 71865-37-7 is a heterobifunctional crosslinking agent featuring both a maleimide group and a disulfide bond. This compound is essential for creating stable, cleavable conjugates in bioconjugation and materials science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced polymer industries for developing targeted drug delivery systems, diagnostic assays, and functionalized materials.

Application

• Bioconjugation and Protein Modification: For site-specific crosslinking of antibodies, enzymes, and other proteins to drugs, polymers, or solid surfaces via thiol-maleimide chemistry.
• Antibody-Drug Conjugate (ADC) Development: Serves as a cleavable linker, enabling the controlled release of cytotoxic payloads in targeted cancer therapies.
• Surface Functionalization: Used to modify nanoparticles, quantum dots, and biosensor surfaces to create reversible or responsive interfaces.
• Polymer Chemistry: Acts as a crosslinker or chain extender in the synthesis of stimuli-responsive hydrogels and smart polymers.
• Diagnostic Reagent Synthesis: Employed in the preparation of enzyme-labeled antibodies and other detection probes for immunoassays.
• Peptide and Oligonucleotide Conjugation: Facilitates the attachment of peptides or oligonucleotides to carriers or other biomolecules.

Basic Information

Product Name	Dithio-Bis-Maleimidoethane
CAS No.	71865-37-7
Molecular Formula	C10H10N2O4S2
Molecular Weight	286.33 g/mol
Synonyms	1,2-Bis(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl disulfide; Bis(maleimidoethyl) disulfide; BM(PEG)2; DTME; 1,1'-[Dithiobis(ethylene-2,1-diyl)]bismaleimide; 1,1'-(Dithiodi-2,1-ethanediyl)bismaleimide; N,N'-(1,2-Dithiodiethyl)dimaleimide; 1,1'-(1,2-Dithiodiethyl)dimaleimide
EINECS	Contact for details

Quality Control

Our Dithio-Bis-Maleimidoethane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) under an inert atmosphere for long-term stability. The product is moisture-sensitive and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.