Description

(S)-4-Hydroxymandelonitrile is a chiral cyanohydrin derivative and a key synthetic intermediate in organic chemistry. This compound matters for its role as a versatile building block in the enantioselective synthesis of complex molecules, particularly in pharmaceutical development. Industries that need it include pharmaceutical R&D, agrochemical manufacturing, and fine chemical synthesis for producing active pharmaceutical ingredients (APIs) and other high-value chiral compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor for synthesizing enantiomerically pure drugs, including β-blockers and other cardiovascular or neurological agents.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Building Block: Serves as a starting material for the synthesis of complex natural products, flavors, and fragrances.
• Asymmetric Catalysis Research: Employed as a standard substrate or ligand precursor in developing and testing new chiral catalysts and methodologies.
• Biochemical Research: Used in studies related to enzyme inhibition and the synthesis of labeled compounds for metabolic pathway analysis.

Basic Information

Product Name	(S)-4-Hydroxymandelonitrile
CAS No.	71807-09-5
Molecular Formula	C8H7NO2
Molecular Weight	149.15 g/mol
Synonyms	(S)-(-)-4-Hydroxymandelonitrile; (S)-4-Hydroxybenzaldehyde cyanohydrin; (S)-α-Hydroxy-4-hydroxybenzeneacetonitrile; (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetonitrile; (S)-p-Hydroxymandelonitrile; Mandelonitrile, 4-hydroxy-, (S)-; L-4-Hydroxymandelonitrile
EINECS	Contact for details

Quality Control

Our (S)-4-Hydroxymandelonitrile is produced under strict quality management systems to ensure high chemical and enantiomeric purity. Each batch is characterized by advanced analytical techniques including HPLC, chiral chromatography, and NMR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.