Description

1-(Pentafluoropropionyl)Imidazole is a high-purity fluorinated acylating reagent and a key synthetic intermediate. Its value lies in its ability to efficiently introduce the pentafluoropropionyl group into target molecules, a critical step in the development of advanced materials and pharmaceuticals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for synthesizing compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for improved drug properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides where the pentafluoropropionyl group contributes to efficacy and environmental profile.
• Peptide & Protein Modification: Serves as an acylating agent for modifying amino acids, peptides, or proteins to alter their physical, chemical, or biological characteristics.
• Material Science: Employed in the synthesis of fluorinated polymers, liquid crystals, and other advanced materials that require specific surface properties or stability.
• Analytical Chemistry: Used as a derivatization agent in gas chromatography (GC) and mass spectrometry (MS) to enhance the detection and analysis of complex compounds.
• Cross-Coupling Reactions: Acts as a reagent in metal-catalyzed cross-coupling reactions to construct complex molecular architectures.

Basic Information

Product Name	1-(Pentafluoropropionyl)Imidazole
CAS No.	71735-32-5
Molecular Formula	C6H3F5N2O
Molecular Weight	214.10 g/mol
Synonyms	Pentafluoropropionyl Imidazole; 1H-Imidazole, 1-(2,2,3,3,3-pentafluoropropanoyl)-; 2,2,3,3,3-Pentafluoropropanoic Acid Imidazolide; 1-(Perfluoropropionyl)imidazole; Imidazole, 1-(pentafluoropropionyl)-; PFP-Imidazole; Pentafluoropropionic Acid Imidazolide; 1-(Pentafluoropropanoyl)imidazole
EINECS	Contact for details

Quality Control

Our 1-(Pentafluoropropionyl)Imidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.