Description

Boc-Ser(Bzl)-Gly-Arg-Nh-Np.Hcl* is a protected peptide derivative, specifically a Boc-Ser(Bzl)-Gly-Arg p-nitroanilide hydrochloride salt. This compound is a critical synthetic intermediate and a specialized substrate for protease research. It is primarily utilized in pharmaceutical R&D for the development and screening of enzyme inhibitors, particularly those targeting serine proteases like thrombin and trypsin. Researchers in biochemistry and medicinal chemistry rely on this high-purity building block for peptide synthesis and mechanistic studies.

Application

• Protease Substrate: Used as a chromogenic p-nitroanilide (pNA) substrate for the kinetic assay and characterization of serine proteases, including thrombin, trypsin, and related enzymes.
• Pharmaceutical Intermediate: Serves as a key protected fragment in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates.
• Enzyme Inhibitor Screening: Employed in high-throughput screening (HTS) platforms to identify and evaluate potential protease inhibitors for therapeutic applications.
• Biochemical Research: A vital tool for studying enzyme kinetics, specificity, and catalytic mechanisms in academic and industrial research laboratories.
• Diagnostic Reagent Development: Used in the formulation of diagnostic kits and assays that measure protease activity in clinical samples.

Basic Information

Product Name	Boc-Ser(Bzl)-Gly-Arg-Nh-Np.Hcl*
CAS No.	71730-93-3
Molecular Formula	C30H50N8O8 • HCl
Molecular Weight	671.2 g/mol (free base)
Synonyms	Boc-Ser(Bzl)-Gly-Arg-pNA • HCl; tert-Butyloxycarbonyl-O-benzyl-L-seryl-glycyl-L-arginine 4-nitroanilide hydrochloride; Boc-Ser(Bzl)-Gly-Arg-p-nitroanilide hydrochloride; Boc-Ser(Bzl)-Gly-Arg-NH-Np HCl; Thrombin substrate analog; Protease substrate 71730-93-3; Nα-Boc-Nω-nitro-L-arginyl-glycyl-O-benzyl-L-serine 4-nitroanilide hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Boc-Ser(Bzl)-Gly-Arg-Nh-Np.Hcl* is manufactured and tested under strict quality management systems. We guarantee high chemical purity and batch-to-batch consistency suitable for sensitive research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.