Description

(S)-Amisulpride CAS NO 71675-92-8 is a high-purity enantiomer of the atypical antipsychotic agent amisulpride, specifically the (S)-(-) stereoisomer. This compound is of critical importance in pharmaceutical research and development for studying stereospecific receptor binding, pharmacokinetics, and therapeutic efficacy. It serves as a vital reference standard and key chiral intermediate for researchers and manufacturers in the neuropharmacology sector, enabling the development of more targeted and potent therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral building block in the synthesis of enantiomerically pure amisulpride and related compounds.
• Pharmacological Research: Essential for in vitro and in vivo studies to investigate the distinct biological activity, receptor affinity (D2/D3 dopamine receptor antagonism), and metabolic profile of the (S)-enantiomer.
• Analytical Chemistry: Employed in chromatographic separations (HPLC, Chiral GC) as a pure standard to calibrate systems and quantify the enantiomeric purity of amisulpride samples.
• Process Development & Optimization: Used in R&D to develop and scale up asymmetric synthesis routes for chiral pharmaceuticals.
• Regulatory Submissions: Provides essential data and materials for drug master files (DMFs) and regulatory dossiers to support new drug applications (NDAs).

Basic Information

Product Name	(S)-Amisulpride
CAS No.	71675-92-8
Molecular Formula	C17H27N3O4S
Molecular Weight	369.48 g/mol
Synonyms	(S)-(-)-Amisulpride; (S)-Amisulpride; (-)-Amisulpride; Levamisulpride; (S)-4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide; (S)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide; (S)-(-)-Socian; DAN 2163 (S-enantiomer)
EINECS	Contact for details

Quality Control

Our (S)-Amisulpride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, identity confirmation, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.