Description

(R)-4-Phenylpyrrolidin-2-One CAS NO 71657-88-0 is a high-purity chiral intermediate belonging to the pyrrolidinone class of compounds. Its defined stereochemistry makes it a critical building block for the synthesis of advanced pharmaceutical active ingredients and fine chemicals. This product is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of central nervous system (CNS) active drugs, including potential dopamine receptor ligands and other neuropharmaceuticals.
• Asymmetric Synthesis: Serves as a versatile precursor for constructing complex molecules with defined stereocenters via further functionalization of the pyrrolidinone ring.
• Agrochemical Research: Used in the development of novel chiral pesticides and herbicides where specific enantiomeric activity is desired.
• Ligand and Catalyst Development: Acts as a starting material for creating chiral ligands used in asymmetric catalysis and metal-organic frameworks.
• Academic & R&D: Employed in university and corporate research laboratories for methodological studies in organic and medicinal chemistry.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals for electronics, materials science, and other high-tech applications.

Basic Information

Product Name	(R)-4-Phenylpyrrolidin-2-One
CAS No.	71657-88-0
Molecular Formula	C10H11NO
Molecular Weight	161.20 g/mol
Synonyms	(R)-4-Phenyl-2-pyrrolidinone; (R)-4-Phenyl-2-pyrrolidone; (R)-4-Phenyl-dihydro-2(3H)-furanone; (R)-4-Phenylbutyrolactam; (R)-4-Phenyl-γ-butyrolactam; (R)-4-Phenyl-Azetidin-2-one (common misnomer); (R)-4-Phenylpyrrolidinone; (R)-4-Phenyl-2-oxopyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-4-Phenylpyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.