Description

Diphenylmethyl (6R-Trans)-7-Amino-3-Methoxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is a key pharmaceutical intermediate, specifically a protected derivative of a cephalosporin nucleus. This compound matters for its critical role in the synthesis of advanced β-lactam antibiotics, where it serves as a versatile building block for introducing specific stereochemistry and functional groups. Pharmaceutical R&D and manufacturing teams need this high-purity intermediate to develop and produce next-generation antibacterial agents targeting resistant pathogens.

Application

• Pharmaceutical Intermediate: Primary use as a protected synthon in the multi-step synthesis of novel cephalosporin and cephem antibiotics.
• Antibiotic Research & Development: Serves as a crucial starting material or advanced intermediate for medicinal chemists developing new antibacterial compounds with improved efficacy.
• Process Chemistry & Scale-Up: Used in the development and optimization of commercial-scale manufacturing processes for active pharmaceutical ingredients (APIs).
• Reference Standard: High-purity grades are utilized as analytical reference standards for quality control and method validation in API production.
• Custom Synthesis: A building block for the custom synthesis of specialized β-lactam structures for preclinical and clinical studies.

Basic Information

Product Name	Diphenylmethyl (6R-Trans)-7-Amino-3-Methoxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride
CAS No.	71613-81-5
Molecular Formula	C₂₂H₂₃ClN₂O₅S
Molecular Weight	462.95 g/mol
Synonyms	(6R,7R)-7-Amino-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester hydrochloride; Diphenylmethyl 7β-Amino-3-methoxycephem-4-carboxylate Hydrochloride; DPMC Hydrochloride; 7-ADCA Diphenylmethyl Ester 3-Methoxy Derivative Hydrochloride; 7-ACA Diphenylmethyl Ester 3-Methoxy Derivative Hydrochloride; (6R-trans)-7-Amino-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, benzhydryl ester, monohydrochloride; Benzhydryl 7β-Amino-3-methoxy-3-cephem-4-carboxylate Hydrochloride
EINECS	Contact for details

Quality Control

Our Diphenylmethyl (6R-Trans)-7-Amino-3-Methoxy-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each batch, detailing comprehensive specifications. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.