Description

Tolmetin Glucuronide is a major, pharmacologically inactive metabolite of the non-steroidal anti-inflammatory drug (NSAID) Tolmetin. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It serves as a critical reference standard and analytical marker for laboratories involved in drug metabolism, bioanalytical method development, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the qualitative and quantitative analysis of Tolmetin and its metabolites.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for studying the glucuronidation pathway, metabolic clearance, and excretion profiles of Tolmetin.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for the accurate detection and quantification of drug metabolites in biological matrices.
• Toxicology Studies: Employed in safety assessments to understand the complete metabolic fate and potential interactions of Tolmetin.
• Impurity Profiling: Acts as a known impurity or degradation product standard in the quality control of Tolmetin sodium active pharmaceutical ingredient (API) and finished dosage forms.
• Clinical Research: Supports studies investigating patient variability in drug metabolism and the impact of glucuronidation on drug efficacy and safety.

Basic Information

Product Name	Tolmetin Glucuronide
CAS No.	71595-19-2
Molecular Formula	C₂₃H₂₄NO₉
Molecular Weight	458.44 g/mol
Synonyms	1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid β-D-glucopyranosiduronic acid; Tolmetin 1-O-β-Acid Glucuronide; Tolmetin Glucuronide Ester; (1-Methyl-2-pyrrolyl)-p-toluoylacetic acid glucuronide; Tolmetin β-D-Glucuronide; Tolmetin metabolite glucuronide; Tolectin glucuronide
EINECS	Contact for details

Quality Control

Our Tolmetin Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets high-purity standards suitable for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.