Description

7-Amino-3-[1-(Sulfomethyl)-1H-Tetrazol-5-Ylthiomethyl]-3-Cephem-4-Carboxylic Acid, Sodium Salt is a key advanced pharmaceutical intermediate (API intermediate) in the synthesis of modern cephalosporin antibiotics. Its value lies in its role as a crucial building block for developing broad-spectrum, β-lactamase-inhibitor combination drugs, which are essential in combating resistant bacterial infections. This compound is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation injectable antibiotics.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of third and fourth-generation cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the manufacturing process of final drug substances like cefoperazone and other sulfomethyl tetrazole-containing cephalosporins.
• Antibacterial Drug Development: A vital component in R&D for creating new antibiotic formulations with enhanced efficacy against resistant strains.
• Biochemical Research: Employed in studies related to β-lactam antibiotic mechanisms, structure-activity relationships (SAR), and microbial resistance.
• Veterinary Medicine: Used in the development of antibacterial treatments for animal health.

Basic Information

Product Name	7-Amino-3-[1-(Sulfomethyl)-1H-Tetrazol-5-Ylthiomethyl]-3-Cephem-4-Carboxylic Acid, Sodium Salt
CAS No.	71420-85-4
Molecular Formula	C11H11N7NaO6S3
Molecular Weight	464.43 g/mol
Synonyms	7-ACA Sulfomethyl Tetrazole Derivative; Sodium 7-Amino-3-[(1-sulfomethyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylate; 7-ATCA Sodium Salt; Cefoperazone Intermediate; 7-ACA-(1-SMT); (6R,7R)-7-Amino-3-[[(1-sulfomethyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; 7-ADCA Sulfomethyl Tetrazole Ester; 71420-85-4
EINECS	Contact for details

Quality Control

Our 7-Amino-3-[1-(Sulfomethyl)-1H-Tetrazol-5-Ylthiomethyl]-3-Cephem-4-Carboxylic Acid, Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) are provided with each shipment, detailing specifications for assay, related substances, and residual solvents. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.