Description

2-Aminofluorene n-Glucuronide is a crucial glucuronide conjugate metabolite of 2-aminofluorene, a model aromatic amine. This compound is of significant value in toxicological and metabolic research, serving as a key reference standard for studying Phase II detoxification pathways and DNA adduct formation. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and contract research organizations (CROs) focused on carcinogenesis, drug metabolism, and safety assessment.

Application

• Biomarker Reference Standard: Used as a high-purity analytical standard for the quantification of 2-aminofluorene metabolites in biological matrices (e.g., urine, plasma) in exposure and metabolic studies.
• Toxicology Research: Essential for investigating the metabolic activation and detoxification pathways of aromatic amines, aiding in the understanding of their carcinogenic mechanisms.
• DNA Adduct Studies: Serves as a precursor or reference in studies analyzing the formation and repair of DNA adducts, which are critical events in chemical carcinogenesis.
• Enzyme Activity Assays: Utilized in in vitro assays to study the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.
• Method Development & Validation: Employed in the development and validation of sensitive analytical methods, such as LC-MS/MS and HPLC, for metabolite profiling.
• Regulatory Safety Testing: Supports safety assessment packages for regulatory submissions by providing definitive metabolite identification and quantification.

Basic Information

Product Name	2-Aminofluorene n-Glucuronide
CAS No.	71388-05-1
Molecular Formula	C₂₀H₂₁NO₇
Molecular Weight	387.38 g/mol
Synonyms	2-AF N-Glucuronide; N-(9H-Fluoren-2-yl)-β-D-glucopyranosiduronic acid; 2-Aminofluorene Glucuronide; 2-AF-Gluc; 2-Aminofluorenyl glucuronide; N-(2-Fluorenyl)-β-D-glucopyranosiduronic acid; β-Glucuronidase substrate (2-AF derived)
EINECS	Contact for details

Quality Control

Every batch of our 2-Aminofluorene n-Glucuronide is produced and analyzed under strict quality management protocols. We guarantee high chemical purity and stability, supported by comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.