Description

Clostridium Perfringens θ-Toxin is a potent, pore-forming cytolysin produced by the anaerobic bacterium *Clostridium perfringens*. This highly specific exotoxin is a critical reagent for research into bacterial pathogenesis, host cell membrane interactions, and the development of diagnostic tools. It is essential for laboratories in the pharmaceutical, biotechnology, and academic research sectors focused on microbiology, immunology, and vaccine development.

Application

• Biomedical Research: Fundamental studies on bacterial toxin mechanisms, membrane permeability, and cytolytic activity.
• Diagnostic Development: Used as a key antigen or standard in the development and validation of immunoassays for detecting *C. perfringens* infections.
• Vaccine Research: Serves as a target antigen in the research and development of vaccines and antitoxins against clostridial diseases.
• Cell Biology Studies: A tool for investigating cholesterol-dependent cytolysins (CDCs) and their role in host-pathogen interactions.
• Quality Control in Biologics: Employed as a reference standard in the quality control testing of related biological products and diagnostic kits.
• Toxicology Studies: Used to assess cellular toxicity and to study the effects of pore-forming toxins on various cell lines.

Basic Information

Product Name	Clostridium Perfringens θ-Toxin
CAS No.	71329-60-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Perfringolysin O; PFO; Theta toxin; Clostridium perfringens θ-toxin; Cholesterol-dependent cytolysin (CDC) from C. perfringens; CPO
EINECS	Contact for details

Quality Control

Our Clostridium Perfringens θ-Toxin is produced and handled under stringent conditions to ensure research-grade purity and biological activity. Each batch is subjected to rigorous analytical testing, including activity assays and purity verification. A comprehensive Certificate of Analysis (COA) detailing purity, activity (in hemolytic units or similar), and other relevant specifications is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Due to its hygroscopic nature, the product should be handled in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Positive for specific hemolytic/cytolytic activity
Purity (SDS-PAGE)	≥ 90%
Protein Content	Determined by UV or colorimetric assay
Specific Activity	Defined hemolytic units/mg protein
Endotoxin Level	< 1.0 EU/µg (for cell culture grade)
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.