Description

24,25-Dihydroxyvitamin D2 is a key metabolite in the vitamin D2 (ergocalciferol) metabolic pathway, specifically formed through the action of the enzyme 25-hydroxyvitamin D 24-hydroxylase. This compound is of significant interest in biochemical research for its role in calcium homeostasis and vitamin D metabolism studies. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and nutraceutical industries, particularly those developing or analyzing vitamin D analogs and related therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantitative and qualitative analysis of vitamin D metabolites in drug development and quality control laboratories.
• Biochemical Research: Essential for in vitro and in vivo studies investigating the catabolism, biological activity, and regulatory functions of vitamin D2 and its derivatives.
• Metabolite Analysis: A critical calibrant in LC-MS/MS and HPLC methods for the accurate measurement of 24,25-dihydroxyvitamin D2 levels in clinical and preclinical samples.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the manufacture of more complex vitamin D analogs and related compounds for therapeutic applications.
• Nutraceutical Research: Employed in studies aiming to understand the bioavailability and metabolic fate of vitamin D2 in dietary supplements and fortified foods.

Basic Information

Product Name	24,25-Dihydroxyvitamin D2
CAS No.	71183-99-8
Molecular Formula	C28H44O3
Molecular Weight	428.65 g/mol
Synonyms	24R,25-Dihydroxyergocalciferol; 24R,25-Dihydroxyvitamin D2; (24R)-24,25-Dihydroxyvitamin D2; 24,25-(OH)2D2; 24,25-Dihydroxyergocalciferol; 24,25-Dihydroxycholecalciferol D2; 24,25-Dihydroxyvitamin D2; 24,25(OH)2D2
EINECS	Contact for details

Quality Control

Our 24,25-Dihydroxyvitamin D2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific pharmacopeial or client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to maintain stability. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.