Description

1-Cbz-2-Piperidinecarboxylic Acid is a protected amino acid derivative of significant importance in synthetic organic and medicinal chemistry. This compound serves as a crucial chiral building block for the construction of complex molecules, particularly in peptide and peptidomimetic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting the central nervous system.
• Peptide Chemistry: Used for the introduction of the pipecolic acid (homoproline) residue into peptide chains with the Cbz (carboxybenzyl) group serving as a temporary amine protector.
• Protease Inhibitor Development: Acts as a core structural component in the design and synthesis of inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed in the preparation of labeled compounds, molecular probes, and bioactive scaffolds for structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of specialized, high-value fine chemicals and custom research compounds.

Basic Information

Product Name	1-Cbz-2-Piperidinecarboxylic Acid
CAS No.	71170-88-2
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-2-piperidinecarboxylic Acid; N-Carbobenzyloxy-DL-pipecolic Acid; N-Cbz-2-Piperidinecarboxylic Acid; N-Cbz-Pipecolic Acid; 1-Carbobenzyloxypipecolic Acid; (±)-1-[(Benzyloxy)carbonyl]pipecolic Acid; N-Cbz-DL-Pipecolinic Acid; 1-Cbz-Pipecolic Acid
EINECS	Contact for details

Quality Control

Our 1-Cbz-2-Piperidinecarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Racemic mixture (DL)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.