Description

12-(Tetrahydro-2H-Pyran-2-Yloxy)-1-Dodecyne is a high-purity, protected terminal alkyne building block, essential for advanced organic synthesis. Its core value lies in the THP-protected hydroxyl group, which provides excellent stability during complex reaction sequences while allowing for selective deprotection under mild acidic conditions. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures, including natural products and novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of bioactive molecules, macrocycles, and drug candidates via Sonogashira, Click, and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and plant growth regulators that incorporate alkyne functionalities.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalization agent for creating specialty polymers, dendrimers, and surface-modified materials with tailored properties.
• Liquid Crystal & OLED Research: Employed in the synthesis of advanced organic electronic materials and liquid crystal compounds requiring precise molecular length and terminal alkynes.
• Bioconjugation & Probe Development: Acts as a linker or labeling reagent for attaching fluorescent tags, biotin, or other moieties to biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Academic & Process Chemistry: A versatile building block for methodological development, catalysis research, and scaling novel synthetic routes in laboratory and pilot plant settings.

Basic Information

Product Name	12-(Tetrahydro-2H-Pyran-2-Yloxy)-1-Dodecyne
CAS No.	71084-07-6
Molecular Formula	C₁₇H₃₀O₂
Molecular Weight	266.42 g/mol
Synonyms	1-Dodecyne, 12-(tetrahydro-2H-pyran-2-yloxy)-; 12-(Tetrahydropyran-2-yloxy)-1-dodecyne; 2-[(1-Dodecyn-12-yl)oxy]tetrahydro-2H-pyran; THP-protected 11-undecyn-1-ol; 11-(Tetrahydro-2H-pyran-2-yloxy)-1-undecyne (common naming variant); Terminal alkyne THP ether C12; Alkyne-PEG-THP (conceptual); 12-(Oxan-2-yloxy)dodec-1-yne (IUPAC style)
EINECS	Contact for details

Quality Control

Our 12-(Tetrahydro-2H-Pyran-2-Yloxy)-1-Dodecyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage under an inert atmosphere (e.g., nitrogen or argon), please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.