Description

Methotrexate-α-Monoamide is a chemically modified derivative of the established pharmaceutical agent methotrexate. This compound is significant for its role as a key intermediate in the research and development of novel therapeutic agents, particularly in the fields of oncology and autoimmune disease treatment. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and targeted drug delivery system development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel methotrexate conjugates and prodrugs for enhanced therapeutic efficacy.
• Targeted Drug Delivery Research: Used in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems where the amide linkage provides a stable attachment point.
• Biochemical Research: Employed in studies investigating folate metabolism inhibition and the structure-activity relationships (SAR) of antifolate compounds.
• Medicinal Chemistry: A valuable precursor for modifying the pharmacokinetic and pharmacodynamic properties of methotrexate-based therapies.
• Reference Standard: Utilized as an analytical standard in quality control and method development for pharmaceutical manufacturing.

Basic Information

Product Name	Methotrexate-α-Monoamide
CAS No.	71074-47-0
Molecular Formula	C₂₁H₂₃N₉O₅
Molecular Weight	505.48 g/mol
Synonyms	N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid α-amide; MTX-α-amide; Methotrexate α-amide; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-amide; Amethopterin α-monoamide
EINECS	Contact for details

Quality Control

Our Methotrexate-α-Monoamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.