Description

(2S,3S)-(+)-2,3-Bis(Diphenylphosphino)-Bicyclo[2.2.1]Hept-5-Ene is a high-value, chiral bidentate phosphine ligand essential for asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in critical bond-forming reactions, leading to the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing and scaling up advanced synthetic processes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical synthesis.
• Cross-Coupling Catalysis: Used in palladium-catalyzed reactions such as Suzuki-Miyaura and Heck couplings to construct complex molecular architectures.
• Hydroformylation: Facilitates the asymmetric hydroformylation of alkenes to produce chiral aldehydes.
• Academic & Process R&D: Serves as a critical tool for developing novel catalytic methodologies and optimizing synthetic routes.
• Agrochemical Synthesis: Employed in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chiral Auxiliary Synthesis: Used in the preparation of other chiral ligands and organocatalysts.

Basic Information

Product Name	(2S,3S)-(+)-2,3-Bis(Diphenylphosphino)-Bicyclo[2.2.1]Hept-5-Ene
CAS No.	71042-54-1
Molecular Formula	C31H28P2
Molecular Weight	462.50 g/mol
Synonyms	(+)-NORPHOS; (2S,3S)-(+)-NORPHOS; (1S,4S)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene; (1S,4S)-2,3-Bis(diphenylphosphino)-5-norbornene; (S,S)-NORPHOS; (S,S)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene; NORPHOS ligand
EINECS	Contact for details

Quality Control

Our (2S,3S)-(+)-NORPHOS is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analytical characterization, including chiral purity verification. Certificates of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container under an inert atmosphere (e.g., nitrogen or argon), protected from light. Store at 2-8°C in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be flushed with inert gas after each opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.