Description

4,4,4-Trifluorocrotonic Acid is a specialized fluorinated organic acid building block of significant interest in advanced chemical synthesis. Its unique structure, featuring a trifluoromethyl group adjacent to a reactive α,β-unsaturated carboxylic acid, makes it a valuable precursor for introducing fluorinated moieties into target molecules. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of novel active ingredients with enhanced properties such as metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting improved drug potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and advanced materials with unique surface properties or chemical resistance.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to create novel fluorinated ligands for catalytic systems.
• Fluorine Chemistry Research: A fundamental reagent in academic and industrial R&D for exploring new reactions and methodologies in fluoroorganic chemistry.
• Fine Chemical Production: Acts as an intermediate in the multi-step synthesis of complex fluorinated fine chemicals for various high-value applications.

Basic Information

Product Name	4,4,4-Trifluorocrotonic Acid
CAS No.	71027-02-6
Molecular Formula	C4H3F3O2
Molecular Weight	140.06 g/mol
Synonyms	2-(Trifluoromethyl)acrylic Acid; 3,3,3-Trifluoro-2-propenoic Acid; (Trifluoromethyl)acrylic Acid; 4,4,4-Trifluorobut-2-enoic Acid; TFAA (in specific contexts); Trifluorocrotonic Acid; α-(Trifluoromethyl)acrylic Acid
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorocrotonic Acid is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with key parameters including assay (by HPLC or titration), identity confirmation (by IR/NMR), and impurity profiles. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, oxidizing agents, and reducing agents. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.