Description

1-Benzyl-2,2-Difluoro-Ethylamine is a versatile fluorinated amine building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoroethylamine moiety, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated amine motifs to enhance metabolic stability, bioavailability, or binding affinity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Chemical Biology: Useful as a probe or linker in bioconjugation chemistry and for labeling biomolecules.
• Fluorine Chemistry Library: A valuable component for constructing diverse compound libraries in medicinal chemistry and drug discovery programs.

Basic Information

Product Name	1-Benzyl-2,2-Difluoro-Ethylamine
CAS No.	71025-65-5
Molecular Formula	C9H11F2N
Molecular Weight	171.19 g/mol
Synonyms	N-(2,2-Difluoroethyl)benzylamine; Benzyl(2,2-difluoroethyl)amine; 2,2-Difluoro-N-(phenylmethyl)ethanamine; α,α-Difluoro-β-benzylethylamine; 71025-65-5; BDFEA; N-Benzyl-2,2-difluoroethylamine
EINECS	Contact for details

Quality Control

Every batch of 1-Benzyl-2,2-Difluoro-Ethylamine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support development and scale-up activities, from laboratory to pilot plant scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.