Description

Ethyl 5,5,5-Trifluoro-4-Hydroxypentanoate is a high-value fluorinated building block and chiral intermediate essential for advanced organic synthesis. Its unique structure, featuring both a trifluoromethyl group and a hydroxyl moiety, makes it a critical precursor for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group improves efficacy and environmental profile.
• Chiral Synthesis: Serves as a versatile chiral synthon for asymmetric synthesis, enabling the construction of enantiomerically pure compounds.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated compounds.
• Liquid Crystal & Material Science: Potential intermediate for synthesizing fluorinated liquid crystals and advanced polymeric materials with specific optical or surface properties.

Basic Information

Product Name	Ethyl 5,5,5-Trifluoro-4-Hydroxypentanoate
CAS No.	70961-06-7
Molecular Formula	C7H11F3O3
Molecular Weight	200.16 g/mol
Synonyms	5,5,5-Trifluoro-4-hydroxypentanoic Acid Ethyl Ester; Ethyl 5,5,5-Trifluoro-4-hydroxyvalerate; 4-Hydroxy-5,5,5-trifluoropentanoic Acid Ethyl Ester; Ethyl 4-Hydroxy-5,5,5-trifluoropentanoate; (RS)-Ethyl 5,5,5-Trifluoro-4-hydroxypentanoate; (±)-Ethyl 5,5,5-Trifluoro-4-hydroxypentanoate; Ethyl 3-(Trifluoromethyl)-3-hydroxypropionate Homolog
EINECS	Contact for details

Quality Control

Our Ethyl 5,5,5-Trifluoro-4-Hydroxypentanoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, ensuring full traceability and compliance with customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. Due to its sensitivity to moisture and potential reactivity, it is recommended to store the material under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.