Description

Ethyl 5,5,5-Trifluoro-4-oxopentanoate is a high-value fluorinated ketoester building block, essential for introducing the trifluoromethyl ketone moiety into complex molecules. Its unique structure offers significant advantages in modulating the lipophilicity, metabolic stability, and binding affinity of target compounds. This intermediate is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, enzyme modulators, and other bioactive molecules containing a trifluoromethyl ketone pharmacophore.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group enhances efficacy and environmental profile.
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, and specialty materials with tailored surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in nucleophilic addition reactions, cyclocondensations, and as a precursor for heterocyclic compounds like pyrazoles and isoxazoles.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring new methodologies in fluoroorganic chemistry.

Basic Information

Product Name	Ethyl 5,5,5-Trifluoro-4-oxopentanoate
CAS No.	70961-05-6
Molecular Formula	C7H9F3O3
Molecular Weight	198.14 g/mol
Synonyms	Ethyl 5,5,5-Trifluoro-4-oxopentanoate; 5,5,5-Trifluoro-4-oxopentanoic Acid Ethyl Ester; Ethyl 4,4,4-Trifluoro-3-oxobutylacetate; Ethyl 3-(Trifluoroacetyl)propionate; 3-(Trifluoroacetyl)propionic Acid Ethyl Ester; 4-Oxo-5,5,5-trifluoropentanoic Acid Ethyl Ester; 70961-05-6
EINECS	Contact for details

Quality Control

Our Ethyl 5,5,5-Trifluoro-4-oxopentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.