Description

(+)-2-Chloropropiononitrile CAS NO 70886-58-7 is a high-purity chiral nitrile building block of significant value in asymmetric synthesis. Its core value proposition lies in its utility as a versatile electrophilic synthon for introducing the chloropropionitrile moiety into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for cardiovascular and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where its chiral center contributes to biological activity and selectivity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in asymmetric catalysis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Material Science: Potential use as a monomer or cross-linking agent in the synthesis of specialized polymers.

Basic Information

Product Name	(+)-2-Chloropropiononitrile
CAS No.	70886-58-7
Molecular Formula	C₃H₄ClN
Molecular Weight	89.52 g/mol
Synonyms	(R)-2-Chloropropiononitrile; (R)-(+)-2-Chloropropanenitrile; (R)-2-Chloropropionitrile; (R)-α-Chloropropionitrile; (+)-(R)-2-Chloropropiononitrile; (R)-2-Chloro-propanenitrile; (2R)-2-Chloropropanenitrile; Dextrorotatory 2-chloropropiononitrile
EINECS	Contact for details

Quality Control

Our (+)-2-Chloropropiononitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical techniques including chiral HPLC, GC, and NMR spectroscopy. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile and light-sensitive nature, containers must be kept tightly sealed and away from heat sources and open flame. Store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Specific Rotation [α]²⁰D	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.