Description

n-α-Cbz-D-2-4-Diaminobutanoic Acid is a protected derivative of the non-proteinogenic amino acid D-2,4-diaminobutanoic acid, featuring a carboxybenzyl (Cbz) protecting group on the α-amino functionality. This compound is a critical chiral building block in the synthesis of complex peptides, peptidomimetics, and active pharmaceutical ingredients (APIs), where it introduces a specific stereochemistry and functional handle for further modification. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of high-value therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and APIs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-2,4-diaminobutyric acid residue into peptide chains.
• Medicinal Chemistry Research: Serves as a building block for creating libraries of compounds for screening against biological targets.
• Bioconjugation: The free side-chain amino group allows for selective conjugation with other molecules, such as fluorophores or drug payloads.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for commercial pharmaceutical manufacturing.
• Biochemical Research: Used in studies of enzyme mechanisms and as a substrate analog in biochemical assays.

Basic Information

Product Name	n-α-Cbz-D-2-4-Diaminobutanoic Acid
CAS No.	70882-66-5
Molecular Formula	C₁₂H₁₆N₂O₄
Molecular Weight	252.27 g/mol
Synonyms	Nα-Cbz-D-2,4-diaminobutyric acid; (R)-2-(((Benzyloxy)carbonyl)amino)-4-aminobutanoic acid; D-2,4-Diaminobutyric acid Nα-carboxybenzyl derivative; Z-D-Dbu-OH; Cbz-D-Dab-OH; N-Carbobenzoxy-D-2,4-diaminobutyric acid; (R)-4-Amino-2-((((benzyloxy)carbonyl)amino)butanoic acid
EINECS	Contact for details

Quality Control

Our n-α-Cbz-D-2-4-Diaminobutanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.