Description

o-Desmethyl Quinidine is a key pharmaceutical intermediate and metabolite of the antiarrhythmic drug Quinidine. This compound is of significant importance for research and development in the fields of pharmacology, drug metabolism studies, and analytical reference standard preparation. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of high-purity reference materials who require reliable, well-characterized chemical entities for their critical work.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis and development of novel antiarrhythmic agents and related therapeutic compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (LC-MS, HPLC) for quantifying Quinidine and its metabolites in pharmacokinetic and toxicokinetic studies.
• Pharmacological Research: Employed in in-vitro and in-vivo studies to investigate the metabolic pathways, efficacy, and safety profile of Quinidine-based therapies.
• Impurity Standard: Acts as a certified reference material (CRM) for the identification and quantification of process-related impurities in Quinidine drug substance and finished dosage forms, ensuring compliance with ICH guidelines.
• Clinical Diagnostics: May be used in the development and calibration of diagnostic assays for therapeutic drug monitoring (TDM) in patients undergoing Quinidine treatment.

Basic Information

Product Name	o-Desmethyl Quinidine
CAS No.	70877-75-7
Molecular Formula	C19H22N2O2
Molecular Weight	310.40 g/mol
Synonyms	10,11-Dihydro-6'-methoxycinchonan-9-ol; (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol; 3-Hydroxyquinidine; Quinidine, 3-hydroxy-; 2-Quinuclidinemethanol, α-[(6-methoxy-4-quinolyl)methyl]-; o-Demethylquinidine; 3'-Hydroxyquinidine; 3-Hydroxyquinidine (Metabolite M1)
EINECS	Contact for details

Quality Control

Our o-Desmethyl Quinidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing the results for identity, assay, and related substances is provided with every shipment to ensure full traceability and compliance with your research or quality control requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.