Description

H-Glu(Ome)-Nh2 Hcl is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of glutamine. This compound is a crucial building block in peptide synthesis, offering a protected side chain that prevents unwanted reactions during the coupling process. It is primarily utilized by pharmaceutical researchers, peptide chemists, and fine chemical manufacturers for the development of novel therapeutic peptides and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of glutamic acid residues.
• Solution-Phase Peptide Synthesis: Used in classical peptide chain assembly for research-scale and industrial production.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in the study of enzyme substrates, receptor ligands, and metabolic pathways.
• Combinatorial Chemistry: A valuable component in libraries for drug discovery and high-throughput screening.
• Cosmetic Peptide Synthesis: Used in the production of bioactive peptides for skincare and cosmetic formulations.

Basic Information

Product Name	H-Glu(Ome)-Nh2 Hcl
CAS No.	70830-50-1
Molecular Formula	C6H13N3O3 • HCl
Molecular Weight	211.64 g/mol (Free base: 175.18)
Synonyms	L-Glutamine methyl ester hydrochloride; H-Gln-OMe•HCl; Fmoc-Gln(Trt)-OH (related precursor); Glutamine methyl ester HCl; (S)-2-Amino-4-carbamoylbutanoic acid methyl ester hydrochloride; Nα-Boc-L-glutamine methyl ester (related Boc-protected form); L-Glutamine, methyl ester, hydrochloride (1:1); 70830-50-1
EINECS	Contact for details

Quality Control

Our H-Glu(Ome)-Nh2 Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric purity, and identity confirmation by IR and NMR. Certificates of Analysis (COA) with detailed specifications are provided to ensure the material meets the stringent requirements for pharmaceutical research and GMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.