Description

5-Hydroxy Debrisoquin is a key metabolite and reference standard of the antihypertensive drug debrisoquine. This compound is of significant importance in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It serves as a critical analytical standard for laboratories in the pharmaceutical and biotechnology sectors, enabling precise quantification and metabolic pathway analysis. Researchers and quality control specialists rely on this high-purity material to ensure the accuracy and reliability of their analytical methods.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of debrisoquine and its metabolites in biological matrices.
• Metabolite Profiling: Essential for in vitro and in vivo metabolic studies to understand the biotransformation pathways of debrisoquine.
• Enzyme Activity Assays: Used in biochemical assays to study the activity and polymorphism of the cytochrome P450 2D6 (CYP2D6) enzyme.
• Pharmacokinetic Research: A critical component in drug development for determining absorption, distribution, metabolism, and excretion (ADME) profiles.
• Analytical Method Development: Serves as a calibration standard in High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and other analytical techniques.
• Quality Control Testing: Used by pharmaceutical manufacturers to verify the purity and identity of debrisoquine active pharmaceutical ingredient (API) and related products.

Basic Information

Product Name	5-Hydroxy Debrisoquin
CAS No.	70746-05-3
Molecular Formula	C12H15N3O
Molecular Weight	217.27 g/mol
Synonyms	5-Hydroxydebrisoquine; 1,2,3,4-Tetrahydro-2-(1H-imidazol-1-ylmethyl)-7-hydroxyisoquinoline; Debrisoquine 5-Hydroxy Metabolite; 7-Hydroxy-1,2,3,4-tetrahydro-2-(imidazol-1-ylmethyl)isoquinoline; 5-OH-Debrisoquin; 5-OH-Debrisoquine; 5-Hydroxy Debrisoquine Sulfate (Salt forms may vary).
EINECS	Contact for details

Quality Control

Our 5-Hydroxy Debrisoquin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and impurities to ensure it meets the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.