Description

Phenindione-D5 is a deuterium-labeled analog of the anticoagulant phenindione, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and precision in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require reliable reference materials for method development and validation.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the analysis of phenindione and its metabolites.
• Pharmacokinetic Research: Enables precise tracking and quantification of drug absorption, distribution, metabolism, and excretion (ADME) in biological matrices.
• Metabolite Identification: Aids in the structural elucidation and quantification of phenindione metabolites in complex biological samples.
• Bioanalytical Method Development: Used to validate and optimize analytical methods, ensuring robustness, accuracy, and regulatory compliance (e.g., FDA, EMA guidelines).
• Clinical Diagnostics & Therapeutic Drug Monitoring (TDM): Supports accurate measurement of drug levels in patient plasma or serum for dose optimization.
• Forensic & Toxicology Analysis: Provides a reliable reference for the confirmatory analysis of phenindione in forensic and toxicological investigations.

Basic Information

Product Name	Phenindione-D5
CAS No.	70711-53-4
Molecular Formula	C15H7D5O2
Molecular Weight	227.27 g/mol
Synonyms	2-Deuterio-3-(2,3,4,5,6-pentadeuteriophenyl)-1H-indene-1,3(2H)-dione; Phenindione-d5; 2-Phenyl-1,3-indandione-d5; Phenylindanedione-D5; 2-Phenylindane-1,3-dione-D5; PID-D5; 2-PHIND-D5; Anticoagulant Reference Standard-D5
EINECS	Contact for details

Quality Control

Every batch of Phenindione-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and solvent content. Our quality commitment ensures the material meets the stringent requirements for use in regulated bioanalytical and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.