Description

(1R,2R)-(-)-1,2-Bis[(n-Diphenylphosphino)Amino]Cyclohexane CAS NO 70708-37-1 is a high-purity, chiral diphosphine ligand of significant importance in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer intermediates and active pharmaceutical ingredients (APIs). This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable and effective chiral auxiliaries for complex synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical synthesis.
• Cross-Coupling Reactions: Used in asymmetric versions of Suzuki, Heck, and other C-C bond-forming reactions to create chiral biaryl structures.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in the production of APIs for cardiovascular, CNS, and antiviral drugs.
• Agrochemical Manufacturing: Employed in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Facilitates the manufacture of chiral flavors, fragrances, and advanced materials.
• Academic & Industrial R&D: Serves as a valuable tool for developing new catalytic methodologies and exploring novel reaction pathways.

Basic Information

Product Name	(1R,2R)-(-)-1,2-Bis[(n-Diphenylphosphino)Amino]Cyclohexane
CAS No.	70708-37-1
Molecular Formula	C30H32N2P2
Molecular Weight	482.54 g/mol
Synonyms	(1R,2R)-(-)-1,2-Bis[(Diphenylphosphino)Amino]Cyclohexane; (R,R)-DACH-phenyl Trost Ligand; (R,R)-1,2-Diaminocyclohexane-N,N'-bis(2-diphenylphosphinobenzoyl); (1R,2R)-1,2-Bis[(2-Diphenylphosphino)benzamido]cyclohexane; (R,R)-DACH-Phenyl Trost Ligand; Trost Ligand (R,R)-DACH-Phenyl; (R,R)-DACH-Ph Trost Ligand; (1R,2R)-(-)-1,2-Diaminocyclohexane-N,N'-bis(2-(diphenylphosphino)benzamide)
EINECS	Contact for details

Quality Control

Our (1R,2R)-(-)-1,2-Bis[(n-Diphenylphosphino)Amino]Cyclohexane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade material specifications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment to guarantee reliable performance in your critical catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.