Description

Ribonuclease S-Peptide (1-14), 12-(β-(3-Pyridyl)-Ala)- is a synthetic, site-specifically modified peptide fragment derived from the RNase S enzyme system. This compound is a critical research tool for studying protein-protein interactions, enzyme reconstitution, and the structural basis of ribonuclease activity. It is primarily utilized by biochemical researchers, pharmaceutical R&D teams, and academic institutions focused on enzymology and peptide chemistry.

Application

• Biochemical Research: Fundamental studies on ribonuclease S-protein and S-peptide interactions and enzyme fragment complementation.
• Enzymology Studies: Investigation of enzyme activity, folding, and reconstitution mechanisms using the RNase S model system.
• Protein-Protein Interaction Analysis: Serving as a well-defined probe or ligand in binding assays and structural biology.
• Peptide Chemistry & Conjugation: A model substrate for developing and testing novel peptide modification and labeling techniques due to its unique pyridyl-alanine residue.
• Academic & Pharmaceutical R&D: Used in laboratories for teaching advanced biochemistry concepts and in early-stage drug discovery targeting nucleic acid metabolism.

Basic Information

Item	Details
Product Name	Ribonuclease S-Peptide (1-14), 12-(β-(3-Pyridyl)-Ala)-
CAS No.	70686-88-3
Molecular Formula	C71H102N22O21S
Molecular Weight	1639.8 g/mol
Synonyms	RNase S-Peptide (1-14), 12-(3-Pyridyl)-D-alanine-; S-Protein Peptide (1-14); Ribonuclease S Peptide Fragment; 12-(β-(3-Pyridyl)alanyl)-RNase S-Peptide (1-14); RNase S-Peptide analog; Pyridylalanine-modified S-Peptide
EINECS	Contact for details

Quality Control

Our Ribonuclease S-Peptide (1-14), 12-(β-(3-Pyridyl)-Ala)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency. Each lot is characterized by advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.