Description

L-Phenylalanine, L-Leucyl-, Phenylmethyl Ester (Monotrifluoroacetate) is a protected dipeptide derivative, specifically a trifluoroacetate salt of a benzyl ester. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), where it serves as an intermediate for constructing more complex peptide sequences. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of novel therapeutic peptides, bioactive probes, and peptidomimetics.

Application

• Pharmaceutical Intermediates: Key raw material in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Peptide Research & Development: Essential building block for academic and industrial research into new peptide structures and functions.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative to control coupling sequence and prevent side reactions.
• Bioconjugation & Labeling: Intermediate for creating peptide conjugates used in diagnostics, imaging, and targeted drug delivery systems.
• Combinatorial Chemistry Libraries: Component for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Tool Development: Synthesis of substrate analogs, enzyme inhibitors, and receptor ligands for biochemical studies.

Basic Information

Product Name	L-Phenylalanine, L-Leucyl-, Phenylmethyl Ester (Monotrifluoroacetate)
CAS No.	70637-28-4
Molecular Formula	C23H27F3N2O4
Molecular Weight	452.47 g/mol
Synonyms	Benzyl L-leucyl-L-phenylalaninate trifluoroacetate; L-Leucyl-L-phenylalanine benzyl ester TFA salt; H-Leu-Phe-OBzl · TFA; Boc-Phe-Leu-OBzl precursor; Fmoc-Phe-Leu-OBzl derivative; (S)-Benzyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate trifluoroacetate; Leu-Phe-OBzl · CF3COOH; Protected Leu-Phe dipeptide benzyl ester
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, L-Leucyl-, Phenylmethyl Ester (Monotrifluoroacetate) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.