Description

(2S)-2α-(1,3-Benzodioxol-5-Yl)-3,3A,4,5-Tetrahydro-5β-Methoxy-3β-Methyl-3Aα-(2-Propenyl)Benzofuran-6(2H)-One is a complex, stereochemically defined benzofuran derivative with the CAS number 70522-39-3. This compound is a valuable high-purity chemical intermediate for advanced organic synthesis, particularly in the development of novel pharmacologically active molecules. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for building complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and synthesis of new therapeutic agents, particularly in central nervous system (CNS) and other specialized drug discovery programs.
• Organic Synthesis Research: Used in academic and industrial laboratories to study complex cyclization reactions and to construct novel benzofuran-based compound libraries.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations due to its defined stereocenters, enabling the creation of enantiomerically pure targets.

Basic Information

Product Name	(2S)-2α-(1,3-Benzodioxol-5-Yl)-3,3A,4,5-Tetrahydro-5β-Methoxy-3β-Methyl-3Aα-(2-Propenyl)Benzofuran-6(2H)-One
CAS No.	70522-39-3
Molecular Formula	C22H24O5
Molecular Weight	368.42 g/mol
Synonyms	2-(1,3-Benzodioxol-5-yl)-3,3a,4,5-tetrahydro-5-methoxy-3-methyl-3a-(2-propen-1-yl)-2H-benzofuran-6-one; (2S,3R,3aR,5S,6aS)-2-(1,3-Benzodioxol-5-yl)-3,3a,4,5-tetrahydro-5-methoxy-3-methyl-3a-(2-propen-1-yl)-2H-benzofuran-6-one; 70522-39-3; Benzofuran-6(2H)-one derivative; Chiral benzofuran intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects with specifications tailored to GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to light and oxidation; prolonged exposure to air or light should be avoided to maintain stability and purity. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.