Description

Boc-α-Cyclohexyl-D-Glycine is a protected, non-proteinogenic amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a cyclohexyl side chain in the D-configuration. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase peptide coupling. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, bioactive peptides, and specialized chemical probes where precise stereochemistry and side-chain functionality are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to incorporate constrained, hydrophobic cyclohexyl motifs into peptide backbones to improve metabolic stability and binding affinity.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid building block for the automated synthesis of custom peptides.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of D-amino acids and aliphatic side chains on biological activity.
• Bioconjugation & Probe Development: Useful for creating labeled peptides or conjugates for diagnostic and biochemical research applications.
• Academic & Industrial R&D: A standard reagent in organic synthesis laboratories for constructing complex molecular architectures.

Basic Information

Product Name	Boc-α-Cyclohexyl-D-Glycine
CAS No.	70491-05-3
Molecular Formula	C₁₃H₂₃NO₄
Molecular Weight	257.33 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid; D-2-(Boc-amino)-2-cyclohexylacetic acid; Boc-D-α-Cyclohexylglycine; N-(tert-Butoxycarbonyl)-D-cyclohexylglycine; Boc-Cyh(D)-OH; N-Boc-D-cyclohexylglycine; (R)-2-(tert-Butoxycarbonylamino)-2-cyclohexylacetic acid; Boc-D-Chg-OH
EINECS	Contact for details

Quality Control

Our Boc-α-Cyclohexyl-D-Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific rotation. We support compliance with relevant guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.