Description

n-Acetyl D-Thyroxine is a chemically modified derivative of the thyroid hormone thyroxine, specifically the D-isomer acetylated at the amino group. This modification is critical for research into stereospecific metabolic pathways and receptor interactions, offering a valuable tool for differentiating biological activity from the naturally occurring L-form. It serves as a key intermediate and reference standard in pharmaceutical development, particularly for metabolic and endocrine disorder research, and is essential for quality control in analytical laboratories.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified material for calibrating analytical instruments (HPLC, LC-MS) and validating assay methods in drug development and quality control laboratories.
• Biochemical Research: Employed in metabolic studies to investigate the stereospecificity of thyroid hormone action, enzyme kinetics, and receptor binding affinity of D-isomer analogues.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the development and production of specialized thyroid hormone analogues and experimental therapeutics.
• Diagnostic Reagent Manufacturing: Utilized in the formulation of calibration solutions and controls for in-vitro diagnostic test kits targeting thyroid function.

Basic Information

Product Name	n-Acetyl D-Thyroxine
CAS No.	70438-74-3
Molecular Formula	C17H16I4NO6
Molecular Weight	857.93 g/mol
Synonyms	D-Thyroxine N-Acetate; Acetyl-D-thyroxine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine N-Acetate; 3,3',5,5'-Tetraiodo-D-thyronine N-Acetate; D-T4 Acetamide; N-Acetyl-3,3',5,5'-tetraiodo-D-thyronine; D-3,5,3',5'-Tetraiodothyronine N-Acetate; Reverse T4 Acetate (D-isomer)
EINECS	Contact for details

Quality Control

Our n-Acetyl D-Thyroxine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and control of related substances and residual solvents, to ensure it meets high-purity standards suitable for research and development. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Optical Rotation	Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.