Description

1-Fluoro-4-(Propane-2-Sulfonyl)Benzene is a high-value fluorinated aromatic sulfone building block, prized for its unique electronic and steric properties that facilitate advanced synthetic transformations. This compound is essential for research and development in medicinal chemistry, serving as a key intermediate for constructing complex molecules with potential therapeutic activity. It is primarily sought by pharmaceutical R&D laboratories, agrochemical manufacturers, and specialty chemical producers engaged in the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom and sulfonyl group enhance bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or precursor in the development of advanced polymers, liquid crystals, and electronic materials requiring specific dielectric or optical properties.
• Cross-Coupling Reactions: Functions as an effective electrophile in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Sulfone Chemistry Exploration: Utilized in academic and industrial research to study novel reaction pathways involving sulfone functional groups, such as nucleophilic substitution and carbanion chemistry.
• Fluorine Chemistry: A valuable reagent for introducing fluorine-containing motifs into complex molecular architectures, leveraging the fluorine atom's influence on metabolic stability and lipophilicity.

Basic Information

Product Name	1-Fluoro-4-(Propane-2-Sulfonyl)Benzene
CAS No.	70399-09-6
Molecular Formula	C9H11FO2S
Molecular Weight	202.25 g/mol
Synonyms	4-Fluorophenyl Isopropyl Sulfone; 1-Fluoro-4-(Isopropylsulfonyl)Benzene; p-Fluorophenyl Isopropyl Sulfone; Isopropyl 4-Fluorophenyl Sulfone; (4-Fluorophenyl)(Propan-2-yl)Sulfone; Benzene, 1-fluoro-4-[(1-methylethyl)sulfonyl]-; 4-Fluorobenzene Isopropyl Sulfone
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-(Propane-2-Sulfonyl)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.