Description

2-Cbz-Amino-But-2-Enoic Acid Methyl Ester is a protected amino acid derivative, specifically a Cbz (carboxybenzyl)-protected dehydroamino acid ester. This compound serves as a crucial chiral building block and versatile intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules, where it facilitates the introduction of constrained, unsaturated amino acid motifs.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel peptide-based drugs and protease inhibitors.
• Peptidomimetic Research: Used to incorporate dehydroamino acid residues into peptide chains to study conformation-activity relationships and enhance metabolic stability.
• Combinatorial Chemistry: Serves as a building block in solid-phase and solution-phase peptide synthesis for creating diverse chemical libraries.
• Academic & R&D: Employed in methodological development and the total synthesis of complex natural products containing unusual amino acids.
• Bioconjugation: Potential use in crafting linkers or modified biomolecules for targeted drug delivery systems.

Basic Information

Product Name	2-Cbz-Amino-But-2-Enoic Acid Methyl Ester
CAS No.	70396-37-1
Molecular Formula	C₁₃H₁₅NO₄
Molecular Weight	249.26 g/mol
Synonyms	Methyl (2Z)-2-[[(benzyloxy)carbonyl]amino]but-2-enoate; (Z)-Methyl 2-(((benzyloxy)carbonyl)amino)but-2-enoate; Methyl (Z)-2-(Cbz-amino)but-2-enoate; 2-(N-Cbz-amino)-2-butenoic acid methyl ester; (Z)-2-((Benzyloxycarbonyl)amino)-2-butenoic acid methyl ester; Cbz-dehydroaminobutyric acid methyl ester; N-Carbobenzoxy-2-amino-2-butenoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Cbz-Amino-But-2-Enoic Acid Methyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.