Description

H-Ile-Pna CAS NO 70324-66-2 is a high-purity, protected amino acid derivative, specifically L-Isoleucine p-nitroanilide, designed for advanced research and synthesis. This compound serves as a critical building block and biochemical tool in the development of novel peptides and enzyme substrates. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require precise and reliable intermediates for their processes.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies, particularly for proteases and peptidases, to investigate enzyme kinetics and mechanisms.
• Proteomics & Diagnostics: Employed in the development of assay kits and diagnostic reagents for detecting specific enzymatic activity in biological samples.
• Fine Chemical Synthesis: Acts as a versatile chiral synthon for constructing more complex organic molecules with defined stereochemistry in medicinal chemistry projects.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic chemistry, biochemistry, and molecular biology.

Basic Information

Product Name	H-Ile-Pna
CAS No.	70324-66-2
Molecular Formula	C15H21N3O4
Molecular Weight	307.35 g/mol
Synonyms	L-Isoleucine p-nitroanilide; H-Ile-pNA; Isoleucine 4-nitroanilide; Ile-pNA; N-(4-Nitrophenyl)-L-isoleucinamide; (2S,3S)-2-Amino-3-methyl-N-(4-nitrophenyl)pentanamide; 70324-66-2; L-Ile-pNA
EINECS	Contact for details

Quality Control

Our H-Ile-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.