Description

(1S,2S)-(+)-1,2-Bis(Diphenylphosphinomethyl)Cyclohexane is a high-value, chiral diphosphine ligand widely recognized for its efficacy in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control. The compound is supplied with a guaranteed high purity to ensure optimal catalytic performance and batch-to-batch consistency.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for manufacturing chiral active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Used as a chiral auxiliary in palladium-catalyzed cross-coupling reactions to construct stereogenic centers under mild conditions.
• Pharmaceutical Intermediate Synthesis: Key catalyst in the production of enantiomerically pure intermediates for cardiovascular, central nervous system (CNS), and antiviral drugs.
• Agrochemical Synthesis: Employed in the synthesis of chiral herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in process chemistry.
• Fine Chemical Production: Facilitates the synthesis of complex, high-value flavor and fragrance compounds with specific stereochemistry.

Basic Information

Item	Details
Product Name	(1S,2S)-(+)-1,2-Bis(Diphenylphosphinomethyl)Cyclohexane
CAS No.	70223-77-7
Molecular Formula	C32H34P2
Molecular Weight	480.56 g/mol
Synonyms	(1S,2S)-Cyclohexane-1,2-diylbis(methylene)bis(diphenylphosphine); (S,S)-BDPCY; (S,S)-CyclohexaneDIOP; (1S,2S)-1,2-Bis[(diphenylphosphino)methyl]cyclohexane; (+)-(1S,2S)-1,2-Bis(diphenylphosphinomethyl)cyclohexane; (S,S)-1,2-Bis(diphenylphosphinomethyl)cyclohexane; (S,S)-Bis(diphenylphosphinomethyl)cyclohexane; ChiraPhos
EINECS	Contact for details

Quality Control

Every batch of (1S,2S)-(+)-1,2-Bis(Diphenylphosphinomethyl)Cyclohexane undergoes rigorous analytical testing to ensure it meets the stringent requirements for chiral ligands in catalysis. Our standard quality control protocol includes assessment of chiral purity (enantiomeric excess), chemical purity, and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results, including HPLC and NMR data, is provided with each shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; therefore, the container should be flushed with inert gas after each opening to maintain purity and catalytic activity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.