Description

D-1-n-Boc-Prolinamide is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecular architectures with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis for introducing proline derivatives with a protected amine group.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design of inhibitors targeting specific proteolytic enzymes.
• Chemical Biology Research: Employed in the synthesis of labeled probes or modified peptides for studying enzyme mechanisms and protein interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective organic reactions.
• Custom Synthesis & Contract Manufacturing: A fundamental component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke organic molecules for clients.

Basic Information

Product Name	D-1-n-Boc-Prolinamide
CAS No.	70138-72-6
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	D-Boc-Pro-NH2; (R)-1-[(tert-Butoxycarbonyl)amino]-1,2-pyrrolidinedicarboxamide; tert-Butyl (R)-2-carbamoylpyrrolidine-1-carboxylate; D-Prolinamide, N-Boc-; Boc-D-Pro-NH2; (R)-2-(tert-Butoxycarbonylamino)pyrrolidine-1-carboxamide; N-Boc-D-prolinamide
EINECS	Contact for details

Quality Control

Our D-1-n-Boc-Prolinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with cGMP and ISO guidelines for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.