Description

Pimonidazole is a nitroimidazole-based compound widely recognized as a crucial chemical marker for detecting hypoxic (low-oxygen) regions in biological tissues. Its primary value lies in its selective bioreduction and binding under hypoxic conditions, making it an indispensable tool for research and diagnostic applications. This compound is essential for pharmaceutical R&D, oncology research, and the development of radiotherapy enhancers targeting solid tumors.

Application

• Hypoxia Marker in Biomedical Research: Used extensively in preclinical studies to identify and quantify hypoxic regions in tumors and other tissues.
• Oncology and Radiotherapy Development: Serves as a key reagent in developing and evaluating therapies that target radioresistant hypoxic tumor cells.
• Diagnostic Probe Development: Employed in the synthesis of conjugates for imaging techniques like immunohistochemistry (IHC) and positron emission tomography (PET).
• Pharmacokinetic and Biodistribution Studies: Utilized to study the behavior of drugs and compounds in low-oxygen microenvironments.
• Reference Standard: Serves as a high-purity analytical standard for quality control in related pharmaceutical manufacturing.

Basic Information

Product Name	Pimonidazole
CAS No.	70132-50-2
Molecular Formula	C12H19N5O3
Molecular Weight	281.31 g/mol
Synonyms	1-[(2-Hydroxy-3-piperidinyl)propyl]-2-nitroimidazole; Ro 03-8799; Pimonidazole Hydrochloride (salt form); Hypoxyprobe™-1; NSC 684681; CCRIS 9387; Hypoxia Marker Pimonidazole
EINECS	Contact for details

Quality Control

Our Pimonidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.