Description

α-Dihydromorphine 6-Glucuronide is a high-purity reference standard and active pharmaceutical ingredient (API) metabolite, critical for advanced analytical and pharmacological research. This compound is essential for precise quantification and metabolic pathway studies of dihydromorphine, a potent opioid analgesic. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and analytical service providers for method development, validation, and quality control testing.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative analysis of dihydromorphine and its metabolites in drug development and bioequivalence studies.
• Forensic Toxicology: Serves as a critical calibrator and control in LC-MS/MS and HPLC methods for the accurate detection and confirmation of opioid use in biological samples.
• Metabolic Research: Employed in in vitro and in vivo studies to investigate the glucuronidation pathway, pharmacokinetics, and bioavailability of opioid therapeutics.
• Quality Control (QC) Testing: Integral for the assay and impurity profiling of dihydromorphine-based pharmaceutical products in GMP manufacturing environments.
• Clinical Research: Used to develop and validate diagnostic assays for monitoring patient therapy and studying drug-drug interactions involving opioid metabolism.

Basic Information

Product Name	α-Dihydromorphine 6-Glucuronide
CAS No.	70001-26-2
Molecular Formula	C23H27NO9
Molecular Weight	461.46 g/mol
Synonyms	Dihydromorphine 6-Glucuronide; 6-Glucuronide Dihydromorphine; α-Dihydromorphine-6-β-D-glucuronide; Dihydromorphine-6-O-β-D-glucuronide; 4,5α-Epoxy-17-methylmorphinan-3,6α-diol 6-Glucuronide; Paramorphan glucuronide; Dihydromorphine glucuronide metabolite
EINECS	Contact for details

Quality Control

Our α-Dihydromorphine 6-Glucuronide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for research and reference materials. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.